In contrast, expression in primordial germ cells was not sexually distinct and both sexes showed DMRT1 increasing through 13.5 dpc and absent by 15.5 dpc. The Traders Elliott wave principle PDF is an original file so it is safe and free to download. A male somatic preference continued throughout development, with DMRT1 evident in Sertoli cells at all ages examined and absent in ovarian somatic cells from 13.5 dpc onward.įree Elliott Wave PDF. By 12.5 dpc, a clear sexual preference for DMRT1 in male somatic cells was observed, with male DMRT1 localized to testicular cords and more abundant in Sertoli cells than germ cells and female DMRT1 diffusely labeled and markedly lower in somatic cells than germ cells. In the indifferent gonad (10.5–11.5 dpc), DMRT1 localized to somatic cells and GCNA1 + germ cells and was indistinguishable in males and females. Immunohistochemistry was used to examine GCNA1, a germ cell specific protein, together with DMRT1, a transcription factor implicated in Sertoli cell and germ cell function, in order to resolve DMRT1’s cellular profile during pre- and postnatal gonad development in the mouse.
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